Various Emergency Services including Emer-G-Med responded to reports of a serious collision on the R21 highway before the R24 split in Kempton Park.
On Paramedics arrival, one person was found to have sustained fatal injuries and was declared dead on the scene. Multiple other patients were found with critical injuries.
While paramedics gave their best efforts to stabilize the critically injured patients, three more patients passed away which bring the death toll to four.
Seven critically injured and four moderately injured patients were transported to hospital for treatment they require.